Welcome to Yue Lab at Penn State

Recent News: 1. We received a big data initiative award from Penn State CTSI.
2. Our work in collaboration with Dr. Sander has been acceptd by Cell Stem Cell! Feng is a co-first author.
3. Dr. Feng Yue has been named a recipient of the 2015 PhRMA Foundation Research Starter Grant!
4. The mouse ENCODE main integrative analysis paper been acceptd by Nature! Feng is the lead co-first author and Yanli is a co-author in the paper.
5. Our work in collaboration with Dr. David Gilbert has been accepted by Nature! Co-authors from the lab: Feng, Yanli.
6. Our work in collaboration with Dr. Jun Yang has been accepted by Blood! Co-authors from the lab: Feng, Yanli.

About the lab: Our lab was established in Oct. 2013 and it has both web lab and dry lab components. Now it has one Principal Investigator, one research assistant professor, two postdoc fellows, two graduate students and one undergraduate student. People in the lab come from both biology and computer science background.

We are part of the Department of Biochemistry and Molecular Biology, Institute for Personalized medicine, College of Medicine at Pennsylvania State University. Our lab is located on the second floor (C2706) in the Hershey Medical Center inside the Institute for Personalized Medicine.

About the PI: Dr. Yue is a tenure-track assistant professor at the Dept. of BMB at Penn State School of Medicine. He is actively involved in the ENCODE project and has been serving as a lead analyst for the mouse ENCODE consortium. Before joining Penn State, Dr. Yue received his postdoctoral training in Dr. Bing Ren's laboratory at UCSD School of Medicine. He is a graduate advisor both in the BMS program and the Genomics and Bioinformatics Program.

Research Interest: We are interested in the following areas:

1) Study the function of non-coding variants in the human genome and how they contribute to diseases such as cancer;
2) Cancer epigenomics: investigate epigenetic marks for certain types of cancer with a hope that it may eventually contribute to drug discovery.
3) Study the 3D structure of the genome organization by 5C/Hi-C, in particular the interactions between enhancers and their target gene promoters;
4) Comparative genomics: investigate the evolutionary landscape of cis-regulatory elements in the mammalian genome;